Product Name
SLC16A12 / MCT12, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human SLC16A12 / MCT12
Product Synonym Names
Anti-SLC16A12 / MCT12 Antibody (aa115-164) IHC-plus; SLC16A12; CJMG; MCT 12; Monocarboxylate transporter 12; MCT12; Human SLC16A12; MCT12
Product Gene Name
anti-SLC16A12 antibody
[Similar Products]
Product Synonym Gene Name
MCT12[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6ZSM3
Species Reactivity
Human, Mouse
Specificity
MOT12 Antibody detects endogenous levels of total MOT12 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic peptide from human MOT12 (aa115-164).
Immunogen
SLC16A12 / MCT12 antibody was raised against synthetic peptide from human MOT12 (aa115-164).
Antigen Modification
aa115-164
Preparation and Storage
Store at -20 degree C for up to one year.
Other Notes
Small volumes of anti-SLC16A12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC16A12 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-SLC16A12 antibody
ELISA (1:20000), IHC-P (1:50 - 1:100, 10 ug/ml)
Immunohistochemistry (IHC) of anti-SLC16A12 antibody
Anti- Anti-SLC16A12 / MCT12 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Immunohistochemistry (IHC) of anti-SLC16A12 antibody
Anti-SLC16A12 / MCT12 antibody IHC of human skeletal muscle tissue. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue. Staining on the right was blocked with peptide.
NCBI/Uniprot data below describe general gene information for SLC16A12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_998771.3
[Other Products]
NCBI GenBank Nucleotide #
NM_213606.3
[Other Products]
UniProt Primary Accession #
Q6ZSM3
[Other Products]
UniProt Secondary Accession #
Q5M9M9; Q5T7J2; Q6ZV76[Other Products]
UniProt Related Accession #
Q6ZSM3[Other Products]
Molecular Weight
53,075 Da
NCBI Official Full Name
monocarboxylate transporter 12
NCBI Official Synonym Full Names
solute carrier family 16, member 12
NCBI Official Symbol
SLC16A12 [Similar Products]
NCBI Official Synonym Symbols
CJMG; MCT12
[Similar Products]
NCBI Protein Information
monocarboxylate transporter 12; monocarboxylic acid transporter 12; solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
UniProt Protein Name
Monocarboxylate transporter 12
UniProt Synonym Protein Names
Creatine transporter 2
Protein Family
Monocarboxylate transporter
UniProt Gene Name
SLC16A12 [Similar Products]
UniProt Synonym Gene Names
MCT 12 [Similar Products]
UniProt Entry Name
MOT12_HUMAN
NCBI Summary for SLC16A12
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
UniProt Comments for SLC16A12
SLC16A12: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG). Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of morphological renal anomalies. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q23.31
Cellular Component: integral to plasma membrane
Molecular Function: creatine transporter activity; symporter activity; lactate transmembrane transporter activity
Disease: Cataract, Juvenile, With Microcornea And Glucosuria
Research Articles on SLC16A12
1. study identified a second creatine transporter monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12; Rssults show SLC6A8 was predominantly found in brain, heart and muscle, while SLC16A12 was more abundant in kidney and retina. In the lens, the two transcripts were found at comparable levels.
Precautions
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