Product Name
FIGF, Recombinant Protein
Full Product Name
Recombinant Human FIGF Protein
Product Synonym Names
VEGFD; Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF
Product Gene Name
FIGF recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
FYDIETLKVI DEEWQRTQCS PRETCVEVAS ELGKSTNTFF KPPCVNVFRC GGCCNEESLI CMNTSTSYIS KQLFEISVPL TSVPELVPVK VANHTGCKCL PTAPRHPYSH HHHHH
3D Structure
ModBase 3D Structure for O43915
Purity/Purification
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Endotoxin
Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
Directions for Use
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Preparation and Storage
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
Other Notes
Small volumes of FIGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FIGF recombinant protein
Recombinant Human FIGF Protein is produced by our mammalian expression system in human cells and the target gene encoding Phe93-Ser201 is expressed with a 6His tag at the C-terminus.
Applications Tested/Suitable for FIGF recombinant protein
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
NCBI/Uniprot data below describe general gene information for FIGF. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004460.1
[Other Products]
NCBI GenBank Nucleotide #
NM_004469.4
[Other Products]
UniProt Primary Accession #
O43915
[Other Products]
UniProt Secondary Accession #
B2R7Z3[Other Products]
UniProt Related Accession #
O43915[Other Products]
Molecular Weight
40,444 Da
NCBI Official Full Name
vascular endothelial growth factor D preproprotein
NCBI Official Synonym Full Names
vascular endothelial growth factor D
NCBI Official Symbol
VEGFD [Similar Products]
NCBI Official Synonym Symbols
FIGF; VEGF-D
[Similar Products]
NCBI Protein Information
vascular endothelial growth factor D
UniProt Protein Name
Vascular endothelial growth factor D
UniProt Synonym Protein Names
c-Fos-induced growth factor; FIGF
UniProt Gene Name
VEGFD [Similar Products]
UniProt Synonym Gene Names
VEGF-D; FIGF [Similar Products]
UniProt Entry Name
VEGFD_HUMAN
NCBI Summary for FIGF
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
UniProt Comments for FIGF
VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in *****s. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp22.31
Cellular Component: extracellular region
Molecular Function: chemoattractant activity; growth factor activity; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding
Biological Process: angiogenesis; induction of positive chemotaxis; platelet degranulation; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; response to hypoxia; vascular endothelial growth factor receptor signaling pathway
Research Articles on FIGF
1. Taken together, our data suggest that TNF-alpha can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1/VEGF-D pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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