Full Product Name
iNOS Antibody
Product Synonym Names
HEP-NOS; Hepatocyte NOS; Inducible NO synthase; Inducible NOS; iNOS; nitric oxide synthase 2; inducible; nitric oxide synthase 2A (inducible; hepatocytes)
Product Gene Name
anti-iNOS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P35228
Species Reactivity
Human, Mouse, Rat
Specificity
iNOS Antibody detects endogenous levels of total iNOS
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human iNOS
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-iNOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-iNOS antibody
iNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.
Applications Tested/Suitable for anti-iNOS antibody
Western Blot (WB)
Application Notes for anti-iNOS antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-iNOS antibody
Western blot analysis of iNOS expression in NIH-3T3 whole cell lysates, The lane on the left is treated with the antigen-specific peptide.
NCBI/Uniprot data below describe general gene information for iNOS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000616.3
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NCBI GenBank Nucleotide #
NM_000625.4
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UniProt Primary Accession #
P35228
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UniProt Secondary Accession #
O60757; O94994; Q16263; Q16692; Q4TTS5; Q9UD42; A1L3U5; B7ZLY2[Other Products]
UniProt Related Accession #
P35228[Other Products]
NCBI Official Full Name
nitric oxide synthase, inducible
NCBI Official Synonym Full Names
nitric oxide synthase 2
NCBI Official Symbol
NOS2 [Similar Products]
NCBI Official Synonym Symbols
NOS; INOS; NOS2A; HEP-NOS
[Similar Products]
NCBI Protein Information
nitric oxide synthase, inducible
UniProt Protein Name
Nitric oxide synthase, inducible
UniProt Synonym Protein Names
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
Protein Family
Inositol 3-kinase
UniProt Gene Name
NOS2 [Similar Products]
UniProt Synonym Gene Names
NOS2A; HEP-NOS; Inducible NOS; iNOS [Similar Products]
NCBI Summary for iNOS
Nitric oxide is a reactive free radical which acts as a
biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
UniProt Comments for iNOS
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).
Research Articles on iNOS
1. Collectively, our results demonstrated sanggenon C induced apoptosis of colon cancer cells by increased reactive oxygen species generation and decreased nitric oxide production, which is associated with inhibition of inducible nitric oxide synthase expression(iNOS) and activation of mitochondrial apoptosis pathway.
Precautions
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Disclaimer
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