Upstream Stimulatory Factor 1, Polyclonal Antibody

Anti -Upstream Stimulatory Factor 1 (USF1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (161009041..161015757, complement). Location: 1q22-q23

Polyclonal

Rabbit

Recognizes human USF1

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-USF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Upstream stimulatory factor 1 (UFS-1) is a 33.5kD nuclear protein that exhibits site-specific DNA binding activating the transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. USF-1 is a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor.This protein has been associated to familial combined hyperlipidemia.

Antibodies; Abs to Transcription Factors

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)

Suitable for use in ELISA.Western Blot and ic.
Dilution: ELISA: 1:250
Western Blot: 1:500
Immunocytochemistry: 1:100

33,538 Da[Similar Products]

upstream transcription factor 1

upstream stimulatory factor 1; OTTHUMP00000029691; OTTHUMP00000029693; OTTHUMP00000029695; OTTHUMP00000228974; major late transcription factor 1; class B basic helix-loop-helix protein 11

Upstream stimulatory factor 1

BHLHB11; USF  [Similar Products]

USF1_HUMAN

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; glucose metabolic process; late viral mRNA transcription; lipid homeostasis; glucose homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of fibrinolysis; cellular response to insulin stimulus; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; regulation of transcription by carbon catabolites; positive regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of transcription from RNA polymerase II promoter; response to UV

Disease: Hyperlipidemia, Combined, 1

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