Product Name
ANGPTL3, cDNA Clone
Popular Item
Full Product Name
ANGPTL3 cDNA Clone
Product Gene Name
ANGPTL3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgttcacaa ttaagctcct tctttttatt gttcctctag ttatttcctc cagaattgat caagacaatt catcatttga ttctctatct ccagagccaa aatcaagatt tgctatgtta gacgatgtaa aaattttagc caatggcctc cttcagttgg gacatggtct taaagacttt gtccataaga cgaagggcca aattaatgac atatttcaaa aactcaacat atttgatcag tctttttatg atctatcgct gcaaaccagt gaaatcaaag aagaagaaaa ggaactgaga agaactacat ataaactaca agtcaaaaat gaagaggtaa agaatatgtc acttgaactc aactcaaaac ttgaaagcct cctagaagaa aaaattctac ttcaacaaaa agtgaaatat ttagaagagc aactaactaa cttaattcaa aatcaacctg aaactccaga acacccagaa gtaacttcac ttaaaacttt tgtagaaaaa caagataata gcatcaaaga ccttctccag accgtggaag accaatataa acaattaaac caacagcata gtcaaataaa agaaatagaa aatcagctca gaaggactag tattcaagaa cccacagaaa tttctctatc ttccaagcca agagcaccaa gaactactcc ctttcttcag ttgaatgaaa taagaaatgt aaaacatgat ggcattcctg ctgaatgtac caccatttat aacagaggtg aacatacaag tggcatgtat gccatcagac ccagcaactc tcaagttttt catgtctact gtgatgttat atcaggtagt ccatggacat taattcaaca tcgaatagat ggatcacaaa acttcaatga aacgtgggag aactacaaat atggttttgg gaggcttgat ggagaatttt ggttgggcct agagaagata tactccatag tgaagcaatc taattatgtt ttacgaattg agttggaaga ctggaaagac aacaaacatt atattgaata ttctttttac ttgggaaatc acgaaaccaa ctatacgcta catctagttg cgattactgg caatgtcccc aatgcaatcc cggaaaacaa agatttggtg ttttctactt gggatcacaa agcaaaagga cacttcaact gtccagaggg ttattcagga ggctggtggt ggcatgatga gtgtggagaa aacaacctaa atggtaaata taacaaacca agagcaaaat ctaagccaga gaggagaaga ggattatctt ggaagtctca aaatggaagg ttatactcta taaaatcaac caaaatgttg atccatccaa cagattcaga aagctttgaa tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ANGPTL3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ANGPTL3. It may not necessarily be applicable to this product.
NCBI Accession #
BC058287
[Other Products]
UniProt Secondary Accession #
A0JLS0; B1ALJ0; B2RCW1[Other Products]
UniProt Related Accession #
Q9Y5C1[Other Products]
Molecular Weight
53,637 Da
NCBI Official Full Name
Homo sapiens angiopoietin-like 3, mRNA
NCBI Official Synonym Full Names
angiopoietin like 3
NCBI Official Symbol
ANGPTL3 [Similar Products]
NCBI Official Synonym Symbols
ANL3; ANG-5; FHBL2; ANGPT5
[Similar Products]
NCBI Protein Information
angiopoietin-related protein 3
UniProt Protein Name
Angiopoietin-related protein 3
UniProt Synonym Protein Names
Angiopoietin-5; ANG-5
Protein Family
Angiopoietin-related protein
UniProt Gene Name
ANGPTL3 [Similar Products]
UniProt Synonym Gene Names
ANGPT5; ANG-5 [Similar Products]
UniProt Entry Name
ANGL3_HUMAN
NCBI Summary for ANGPTL3
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]
UniProt Comments for ANGPTL3
ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.
Protein type: Cell adhesion; Inhibitor; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cell surface; extracellular space
Molecular Function: enzyme inhibitor activity; growth factor activity; integrin binding; phospholipase inhibitor activity
Biological Process: acylglycerol homeostasis; artery morphogenesis; cell-matrix adhesion; cholesterol homeostasis; cholesterol metabolic process; fatty acid metabolic process; glycerol metabolic process; lipid homeostasis; negative regulation of lipoprotein lipase activity; phospholipid catabolic process; phospholipid homeostasis; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of lipid catabolic process; sequestering of lipid; signal transduction
Disease: Hypobetalipoproteinemia, Familial, 2
Research Articles on ANGPTL3
1. An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4, thereby directing TG to muscles.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
