Full Product Name
Robo2 Polyclonal Antibody
Product Gene Name
anti-Robo2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9HCK4
Other Notes
Small volumes of anti-Robo2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Robo2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001122401.1
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NCBI GenBank Nucleotide #
NM_001128929.3
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UniProt Primary Accession #
Q9HCK4
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UniProt Secondary Accession #
O43608; Q19AB4; Q19AB5[Other Products]
UniProt Related Accession #
Q9HCK4[Other Products]
Molecular Weight
153,120 Da
NCBI Official Full Name
roundabout homolog 2 isoform ROBO2a
NCBI Official Synonym Full Names
roundabout guidance receptor 2
NCBI Official Symbol
ROBO2 [Similar Products]
NCBI Official Synonym Symbols
SAX3
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NCBI Protein Information
roundabout homolog 2
UniProt Protein Name
Roundabout homolog 2
Protein Family
Roundabout
UniProt Gene Name
ROBO2 [Similar Products]
UniProt Synonym Gene Names
KIAA1568 [Similar Products]
NCBI Summary for Robo2
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for Robo2
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
Research Articles on Robo2
1. determined the crystal structure of the tandem Ig4-5 domains (D4-5) of human Robo2 and found that a hydrophobic surface on D4 mediates close homotypic contacts with a reciprocal D4
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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