Upstream Stimulatory Factor 1 (USF1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of USF1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9358247 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Upstream Stimulatory Factor 1 (USF1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing USF1. The ELISA analytical biochemical technique of the MBS9358247 kit is based on USF1 antibody-USF1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect USF1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, USF1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

27,372 Da

upstream transcription factor 1

upstream stimulatory factor 1

Upstream stimulatory factor 1

BHLHB11; USF; bHLHb11  [Similar Products]

USF1_HUMAN

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: bHLH transcription factor binding; double-stranded DNA binding; enzyme binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding

Biological Process: cellular response to insulin stimulus; glucose homeostasis; glucose metabolic process; late viral mRNA transcription; lipid homeostasis; negative regulation of fibrinolysis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by carbon catabolites; regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; response to UV; transcription from RNA polymerase II promoter

Disease: Hyperlipidemia, Combined, 1

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