Product Name
FGFRL1, cDNA Clone
Full Product Name
FGFRL1 cDNA Clone
Product Gene Name
FGFRL1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaggcgcc gggtgatcgc acggcccgtg ggtagctccg tgcggctcaa gtgcgtggcc agcgggcacc ctcggcccga catcacgtgg atgaaggacg accaggcctt gacgcgccca gaggccgctg agcccaggaa gaagaagtgg acactgagcc tgaagaacct gcggccggag gacagcggca aatacacctg ccgcgtgtcg aaccgcgcgg gcgccatcaa cgccacctac aaggtggatg tgatccagcg gacccgttcc aagcccgtgc tcacaggcac gcaccccgtg aacacgacgg tggacttcgg ggggaccacg tccttccagt gcaaggtgcg cagcgacgtg aagccggtga tccagtggct gaagcgcgtg gagtacggcg ccgagggccg ccacaactcc accatcgatg tgggcggcca gaagtttgtg gtgctgccca cgggtgacgt gtggtcgcgg cccgacggct cctacctcaa taagctgctc atcacccgtg cccgccagga cgatgcgggc atgtacatct gccttggcgc caacaccatg ggctacagct tccgcagcgc cttcctcacc gtgctgccag acccaaaacc gcaagggcca cctgtggcct cctcgtcctc ggccactagc ctgccgtggc ccgtggtcat cggcatccca gccggcgctg tcttcatcct gggcaccctg ctcctgtggc tttgccaggc ccagaagaag ccgtgcaccc ccgcgcctgc ccctcccctg cctgggcacc gcccgccggg gacggcccgc gaccgcagcg gagacaagga ccttccctcg ttggccgccc tcagcgctgg ccctggtgtg gggctgtgtg aggagcatgg gtctccggca gccccccagc acttactggg cccaggccca gttgctggcc ctaagttgta ccccaaactc tacacagaca tccacacaca cacacacaca cactctcaca cacactcaca cgtggagggc aaggtccacc agcacatcca ctatcagtgc tag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FGFRL1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FGFRL1. It may not necessarily be applicable to this product.
NCBI Accession #
BC013955
[Other Products]
UniProt Secondary Accession #
Q6PJN1; Q9BXN7; Q9H4D7; B2RAU9[Other Products]
UniProt Related Accession #
Q8N441[Other Products]
Molecular Weight
54,537 Da
NCBI Official Full Name
Homo sapiens fibroblast growth factor receptor-like 1, mRNA
NCBI Official Synonym Full Names
fibroblast growth factor receptor-like 1
NCBI Official Symbol
FGFRL1 [Similar Products]
NCBI Official Synonym Symbols
FHFR; FGFR5
[Similar Products]
NCBI Protein Information
fibroblast growth factor receptor-like 1
UniProt Protein Name
Fibroblast growth factor receptor-like 1
UniProt Synonym Protein Names
FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5; FGFR-5
Protein Family
Fibroblast growth factor receptor
UniProt Gene Name
FGFRL1 [Similar Products]
UniProt Synonym Gene Names
FGFR5; FHFR; FGF receptor-like protein 1; FGFR-5 [Similar Products]
UniProt Entry Name
FGRL1_HUMAN
NCBI Summary for FGFRL1
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FGFRL1
FGFRL1: Has a negative effect on cell proliferation.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: Golgi apparatus; plasma membrane; transport vesicle
Molecular Function: fibroblast growth factor receptor activity; heparin binding
Biological Process: fibroblast growth factor receptor signaling pathway; protein heterooligomerization; protein homooligomerization
Disease: Wolf-hirschhorn Syndrome
Research Articles on FGFRL1
1. functional evidence for a novel FGFRL1 poly-miRTS rs4647940 in a previously known 4p16.3 locus, and experimental and clinical genetics studies have shown both FGFRL1 and hsa-miR-140-5p are important for bone formation.
Precautions
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Disclaimer
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