USF1, Monoclonal Antibody

Upstream stimulatory factor 1; Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1; USF1; BHLHB11; USF

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

1264CT170.274.14

Mouse

This USF1 antibody is generated from a mice immunized with a recombinant protein between 1-310 amino acids from the Central region of human USF1.

Purified Mouse Monoclonal Antibody (Mab)

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Vial Concentration: 0.41 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-USF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Crown Antibodies; Cancer; Cardiovascular; Metabolism; Microbiology; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:500

Western blot analysis of lysates from Hela,Daudi cell line (from left to right),using CREB3L4 Antibody (monoclonal) (M01)
. MBS9200643 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody.Lysates at 35ug per lane.

33538

upstream transcription factor 1

upstream stimulatory factor 1

Upstream stimulatory factor 1

BHLHB11; USF; bHLHb11  [Similar Products]

USF1_HUMAN

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

USF1: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; histone deacetylase binding; double-stranded DNA binding; bHLH transcription factor binding; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; late viral mRNA transcription; lipid homeostasis; glucose metabolic process; glucose homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of fibrinolysis; cellular response to insulin stimulus; regulation of transcription from RNA polymerase II promoter by glucose; response to hypoxia; regulation of transcription by carbon catabolites; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; response to UV

Disease: Hyperlipidemia, Combined, 1

Gregor P.D.,et al.Genes Dev. 4:1730-1740(1990).
Fukamizu A.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Saito T.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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