Full Product Name
SOS1 Antibody
Product Synonym Names
alternate SOS1; GF1; GGF1; GINGF; gingival fibromatosis; gingival fibromatosis hereditary 1; Guanine nucleotide exchange factor; HGF; NS4; Son of sevenless homolog 1 (Drosophila); Son of sevenless homolog 1; SOS Ras/Rac guanine nucleotide exchange factor 1; SOS-1; Sos1; SOS1_HUMAN
Product Gene Name
anti-SOS1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q07889
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen affinity purified
Immunogen
A synthesized peptide derived from human SOS1
Storage Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-SOS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SOS1 antibody
Western Blot (WB)
Application Notes for anti-SOS1 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for SOS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005624.2
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NCBI GenBank Nucleotide #
NM_005633.3
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UniProt Primary Accession #
Q07889
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UniProt Secondary Accession #
A8K2G3; B4DXG2[Other Products]
UniProt Related Accession #
Q07889[Other Products]
NCBI Official Full Name
son of sevenless homolog 1
NCBI Official Synonym Full Names
SOS Ras/Rac guanine nucleotide exchange factor 1
NCBI Official Symbol
SOS1 [Similar Products]
NCBI Official Synonym Symbols
GF1; HGF; NS4; GGF1; GINGF; SOS-1
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NCBI Protein Information
son of sevenless homolog 1
UniProt Protein Name
Son of sevenless homolog 1
Protein Family
Son of sevenless
UniProt Gene Name
SOS1 [Similar Products]
UniProt Synonym Gene Names
SOS-1 [Similar Products]
NCBI Summary for SOS1
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
UniProt Comments for SOS1
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity ().
Research Articles on SOS1
1. A). The seven common intronic variants were not considered to be of pathogenic importance. The exonic substitution c.138G > A was found to be absent in 100 ethnically matched normal control chromosomes, not expected to have functional significance based on prediction bioinformatics tool">Mutation scanning of the entire coding sequence of SOS1 gene identified seven intronic variants and one new exonic substitution (c.138G > A). The seven common intronic variants were not considered to be of pathogenic importance. The exonic substitution c.138G > A was found to be absent in 100 ethnically matched normal control chromosomes, not expected to have functional significance based on prediction bioinformatics tool
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