C1GALT1 specific chaperone 1 (C1GALT1C1), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of C1GALT1C1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7235179 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the C1GALT1 specific chaperone 1 (C1GALT1C1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing C1GALT1C1. The ELISA analytical biochemical technique of the MBS7235179 kit is based on C1GALT1C1 antibody-C1GALT1C1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C1GALT1C1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C1GALT1C1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

36,382 Da

C1GALT1-specific chaperone 1

C1GALT1-specific chaperone 1; C1Gal-T2; core 1 beta3-Gal-T2; C38H2-like protein 1; beta 1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-galactosyltransferase-specific molecular chaperone

C1GALT1-specific chaperone 1

COSMC; HSPC067; MSTP143; UNQ273/PRO310; C38H2-L1; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2  [Similar Products]

C1GLC_HUMAN

This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]

C1GALT1C1: Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN). Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: protein binding; polypeptide N-acetylgalactosaminyltransferase activity

Biological Process: platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; positive regulation of transferase activity; post-translational protein modification

Disease: Tn Polyagglutination Syndrome

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