Full Product Name
SOS1 Rabbit Polyclonal
Product Gene Name
anti-SOS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Son of sevenless homolog 1 (Drosophila)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SOS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SOS1 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for SOS1. It may not necessarily be applicable to this product.
NCBI Accession #
AAF04460.1
[Other Products]
UniProt Secondary Accession #
A8K2G3; B4DXG2[Other Products]
UniProt Related Accession #
Q07889[Other Products]
Molecular Weight
36,073 Da
NCBI Official Full Name
SOS1, partial
NCBI Official Synonym Full Names
SOS Ras/Rac guanine nucleotide exchange factor 1
NCBI Official Symbol
SOS1 [Similar Products]
NCBI Official Synonym Symbols
GF1; HGF; NS4; GGF1; GINGF
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NCBI Protein Information
son of sevenless homolog 1
UniProt Protein Name
Son of sevenless homolog 1
Protein Family
Son of sevenless
UniProt Gene Name
SOS1 [Similar Products]
UniProt Synonym Gene Names
SOS-1 [Similar Products]
UniProt Entry Name
SOS1_HUMAN
NCBI Summary for SOS1
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
UniProt Comments for SOS1
SOS1: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK.
Protein type: Adaptor/scaffold; GEFs; GEFs, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p21
Cellular Component: cytosol; plasma membrane
Molecular Function: GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity
Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; positive regulation of apoptosis; Ras protein signal transduction; regulation of small GTPase mediated signal transduction
Disease: Fibromatosis, Gingival, 1; Noonan Syndrome 4
Research Articles on SOS1
1. The present study provides a first evidence of allelic imbalance of SOS1 and pinpoints this condition as a possible mechanism underlying a different penetrance of some SOS1-mutated alleles in unrelated carriers
Precautions
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Disclaimer
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