Sos1, Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of Sos1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a synthetic peptide designed for use in combination with anti-Sos1 Antibody, made

Target Description: Sos1 promotes the exchange of Ras-bound GDP by GTP.

Peptide

Western Blot (WB)

151kDa

SOS Ras/Rac guanine nucleotide exchange factor 1

son of sevenless homolog 1

Son of sevenless homolog 1

SOS-1; mSOS-1  [Similar Products]

SOS1: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK.

Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17 E3|17 50.67 cM

Cellular Component: cell soma; cytoplasm; plasma membrane; postsynaptic density

Molecular Function: DNA binding; guanyl-nucleotide exchange factor activity; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding

Biological Process: B cell homeostasis; blood vessel morphogenesis; cardiac atrium morphogenesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; hair follicle development; heart morphogenesis; lymphocyte homeostasis; midbrain morphogenesis; multicellular organism growth; nerve growth factor receptor signaling pathway; palate development; pericardium morphogenesis; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; Ras protein signal transduction; regulation of pro-B cell differentiation; regulation of Rho protein signal transduction; regulation of T cell differentiation in the thymus; regulation of T cell proliferation; small GTPase mediated signal transduction; vitellogenesis

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