Follicle-stimulating hormone receptor (Fshr), Recombinant Protein

Recombinant Follicle-stimulating hormone receptor (Fshr); Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_005105.3 (22754761..22955080, complement). Location: 6q12

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Fshr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

77,681 Da[Similar Products]

follicle stimulating hormone receptor

follicle-stimulating hormone receptor; FSH-R; follitropin receptor

Follicle-stimulating hormone receptor

FSH-R  [Similar Products]

FSHR_RAT

testicular receptor for follicle stimulating hormone; stimulates adenylyl cyclase activity [RGD, Feb 2006]

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Cellular Component: cell surface; cell; integral to membrane; plasma membrane; endosome

Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; follicle-stimulating hormone receptor activity

Biological Process: regulation of estrogen receptor signaling pathway; follicle-stimulating hormone signaling pathway; primary ovarian follicle growth; positive regulation of estrogen receptor signaling pathway; locomotory behavior; regulation of chromosome organization and biogenesis; uterus development; G-protein signaling, adenylate cyclase activating pathway; ovulation cycle process; regulation of osteoclast differentiation; sperm chromatin condensation; ovarian follicle development; negative regulation of bone resorption; neurite development; regulation of protein amino acid phosphorylation; regulation of hormone metabolic process; cellular water homeostasis; spermatogenesis, exchange of chromosomal proteins; male gonad development; Sertoli cell proliferation; transcytosis; Sertoli cell development; G-protein signaling, coupled to cAMP nucleotide second messenger; regulation of MAPKKK cascade; regulation of systemic arterial blood pressure; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); spermatogenesis; G-protein signaling, adenylate cyclase inhibiting pathway; spermatid development

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