Full Product Name
HOXB3 antibody - N-terminal region
Product Gene Name
anti-HOXB3 antibody
[Similar Products]
Product Synonym Gene Name
HOX2; HOX2G; Hox-2.7[Similar Products]
Antibody/Peptide Pairs
HOXB3 peptide (MBS3225346) is used for blocking the activity of HOXB3 antibody (MBS3200357)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GPSKSGPPKC GPGTNSTLTK QIFPWMKESR QTSKLKNNSP GTAEGCGGGG
3D Structure
ModBase 3D Structure for P14651
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human HOXB3
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-HOXB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HOXB3 antibody
This is a rabbit polyclonal antibody against HOXB3. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: HOXB3 belongs to ANTP homeobox family. It is a nuclear protein with a homeobox DNA-binding domain. HOXB3 gene is included in a cluster of homeobox B genes located on chromosome 17. The protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct
biologic subset of acute myeloid leukemia (AML).This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Categories/Family for anti-HOXB3 antibody
Polyclonal; Transcription Factor; Transcription Regulation; Chromatin & Nuclear Signaling; Developmental Biology; DNA/RNA/Protein Interactions; Transcription Factors;
Applications Tested/Suitable for anti-HOXB3 antibody
Western Blot (WB)
Western Blot (WB) of anti-HOXB3 antibody
Host: Rabbit
Target Name: HOXB3
Sample Type: HepG2
Antibody Dilution: 1.0ug/mlHOXB3 is supported by BioGPS gene expression data to be expressed in HepG2

Western Blot (WB) of anti-HOXB3 antibody
WB Suggested Anti-HOXB3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysateHOXB3 is supported by BioGPS gene expression data to be expressed in HepG2

Western Blot (WB) of anti-HOXB3 antibody
WB Suggested Anti-HOXB3 antibody Titration: 1 ug/mL
Sample Type: Human heart

NCBI/Uniprot data below describe general gene information for HOXB3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002137
[Other Products]
NCBI GenBank Nucleotide #
NM_002146
[Other Products]
UniProt Primary Accession #
P14651
[Other Products]
UniProt Related Accession #
P14651[Other Products]
NCBI Official Full Name
homeobox protein Hox-B3 isoform 1
NCBI Official Synonym Full Names
homeobox B3
NCBI Official Symbol
HOXB3 [Similar Products]
NCBI Official Synonym Symbols
HOX2; HOX2G; Hox-2.7
[Similar Products]
NCBI Protein Information
homeobox protein Hox-B3
UniProt Protein Name
Homeobox protein Hox-B3
UniProt Synonym Protein Names
Homeobox protein Hox-2.7; Homeobox protein Hox-2G
Protein Family
Homeobox protein
UniProt Gene Name
HOXB3 [Similar Products]
UniProt Synonym Gene Names
HOX2G [Similar Products]
NCBI Summary for HOXB3
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
UniProt Comments for HOXB3
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Research Articles on HOXB3
1. Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML).
Precautions
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Disclaimer
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