BMPR-IB, Polyclonal Antibody

Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-BMPR-IB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. 

Immunohistochemistry (IHC) Paraffin, ELISA (EIA)

IHC: 1:50-200
ELISA: 1:10000-20000

Immunohistochemistry of paraffin-embedded Human placenta tissue using BMPR-IB Polyclonal Antibody at dilution of 1:100.

Immunohistochemistry of paraffin-embedded Human placenta tissue using BMPR-IB Polyclonal Antibody at dilution of 1:100.

60,582 Da

bone morphogenetic protein receptor type 1B

bone morphogenetic protein receptor type-1B

Bone morphogenetic protein receptor type-1B

BMP type-1B receptor; BMPR-1B  [Similar Products]

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22.3

Cellular Component: cell soma; dendrite; HFE-transferrin receptor complex; integral component of plasma membrane; plasma membrane; receptor complex

Molecular Function: ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity

Biological Process: BMP signaling pathway; cartilage condensation; cellular response to BMP stimulus; chondrocyte development; dorsal/ventral pattern formation; eye development; inflammatory response; limb morphogenesis; negative regulation of chondrocyte proliferation; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; retina development in camera-type eye; retinal ganglion cell axon guidance; skeletal system development

Disease: Brachydactyly, Type A1, D; Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies

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