Full Product Name
IRX1 antibody - N-terminal region
Product Gene Name
anti-IRX1 antibody
[Similar Products]
Product Synonym Gene Name
IRX-5; IRXA1[Similar Products]
Antibody/Peptide Pairs
IRX1 peptide (MBS3226612) is used for blocking the activity of IRX1 antibody (MBS3201604)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: FQYGDPGRPK NATRESTSTL KAWLNEHRKN PYPTKGEKIM LAIITKMTLT
3D Structure
ModBase 3D Structure for P78414
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Protein A purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human IRX1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-IRX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRX1 antibody
This is a rabbit polyclonal antibody against IRX1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: IRX1 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
Product Categories/Family for anti-IRX1 antibody
Polyclonal; Transcription Factor; Transcription Regulation; Developmental Biology;
Applications Tested/Suitable for anti-IRX1 antibody
Western Blot (WB)
Western Blot (WB) of anti-IRX1 antibody
WB Suggested Anti-IRX1 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate
NCBI/Uniprot data below describe general gene information for IRX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077313
[Other Products]
NCBI GenBank Nucleotide #
NM_024337
[Other Products]
UniProt Primary Accession #
P78414
[Other Products]
UniProt Related Accession #
P78414[Other Products]
NCBI Official Full Name
iroquois-class homeodomain protein IRX-1
NCBI Official Synonym Full Names
iroquois homeobox 1
NCBI Official Symbol
IRX1 [Similar Products]
NCBI Official Synonym Symbols
IRX-5; IRXA1
[Similar Products]
NCBI Protein Information
iroquois-class homeodomain protein IRX-1
UniProt Protein Name
Iroquois-class homeodomain protein IRX-1
UniProt Synonym Protein Names
Homeodomain protein IRXA1; Iroquois homeobox protein 1
Protein Family
Iroquois-class homeodomain protein
UniProt Gene Name
IRX1 [Similar Products]
UniProt Synonym Gene Names
IRXA1 [Similar Products]
UniProt Entry Name
IRX1_HUMAN
NCBI Summary for IRX1
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
UniProt Comments for IRX1
IRX1: a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5p15.3
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: regulation of transcription, DNA-dependent
Research Articles on IRX1
1. Multiple evidences suggested that PRMT5 repressed transcription of tumor suppressor IRX1 via recruitment of DNMT3A on promoter.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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