Product Name
CD161/NK1.1, Monoclonal Antibody
Full Product Name
Anti-Mouse CD161/NK1.1 Monoclonal Antibody (AF488 Conjugated) [PK136]
Product Synonym Names
Killer cell lectin-like receptor subfamily B member 1C; Klrb1c; CD161 antigen-like family member C; Ly-55c; CD161/NK1.1; NKR-P1.9; NKR-P1C; NKR-P1 40; CD161c
Product Gene Name
anti-CD161/NK1.1 antibody
[Similar Products]
Product Synonym Gene Name
Mouse CD161/NK1.1[Similar Products]
Matching Pairs
Antibody: CD161/NK1.1 Clone #PK136 (MBS2557944)
Isotype Control: IgG2a, kappa Clone #C1.18.4 (MBS2557782)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P27814
Form/Format
PBS with 0.05% Proclin300, 1% BSA
Concentration
0.5 mg/mL (lot specific)
Preparation and Storage
Store at 2-8 degree C and protect from prolonged exposure to light. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD161/NK1.1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD161/NK1.1 antibody
NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.
Applications Tested/Suitable for anti-CD161/NK1.1 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD161/NK1.1 antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Flow Cytometry (FC/FACS) of anti-CD161/NK1.1 antibody
C57BL/6 murine splenocytes are stained with Anti-Mouse CD161/NK1.1 Monoclonal Antibody(AF488 Conjugated) and Anti-Mouse CD49b Monoclonal Antibody(APC Conjugated). Unstained splenocytes are used as control(Right).
NCBI/Uniprot data below describe general gene information for CD161/NK1.1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001153376.1
[Other Products]
NCBI GenBank Nucleotide #
NP_001153376.1
[Other Products]
UniProt Primary Accession #
P27814
[Other Products]
UniProt Related Accession #
P27814[Other Products]
NCBI Official Full Name
killer cell lectin-like receptor subfamily B member 1C isoform 1
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily B member 1C
NCBI Official Symbol
Klrb1c [Similar Products]
NCBI Official Synonym Symbols
Nk1; Ly59; Nk-1; CD161; Ly-59; Ly55c; NK1.1; NKRP1; Nk1.2; Klrb1b; NK-RP1; Nk-1.2; Nkrp1b; Nkrp1c; ly-55c; NKRP140; AI462337; NKR-P1.9
[Similar Products]
NCBI Protein Information
killer cell lectin-like receptor subfamily B member 1C
UniProt Protein Name
Killer cell lectin-like receptor subfamily B member 1C
UniProt Synonym Protein Names
CD161 antigen-like family member C; Lymphocyte antigen 55c; Ly-55c; NK1.1; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40; NKR-P1 40; CD_antigen: CD161c
UniProt Gene Name
Klrb1c [Similar Products]
UniProt Synonym Gene Names
Ly55c; Nkrp1c; Ly-55c; NKR-P1 40 [Similar Products]
UniProt Entry Name
KLRBC_MOUSE
Research Articles on CD161/NK1.1
1. The adoptive transfer of NK1.1(-) CD4(+) NKG2D(+) cells suppressed DSS-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4(+) NKG2D(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
