Product Name
BMPR1B, cDNA Clone
Full Product Name
BMPR1B cDNA Clone
Product Gene Name
BMPR1B cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcttttgc gaagtgcagg aaaattaaat gtgggcacca agaaagagga tggtgagagt acagccccca ccccccgtcc aaaggtcttg cgttgtaaat gccaccacca ttgtccagaa gactcagtca acaatatttg cagcacagac ggatattgtt tcacgatgat agaagaggat gactctgggt tgcctgtggt cacttctggt tgcctaggac tagaaggctc agattttcag tgtcgggaca ctcccattcc tcatcaaaga agatcaattg aatgctgcac agaaaggaac gaatgtaata aagacctaca ccctacactg cctccattga aaaacagaga ttttgttgat ggacctatac accacagggc tttacttata tctgtgactg tctgtagttt gctcttggtc cttatcatat tattttgtta cttccggtat aaaagacaag aaaccagacc tcgatacagc attgggttag aacaggatga aacttacatt cctcctggag aatccctgag agacttaatt gagcagtctc agagctcagg aagtggatca ggcctccctc tgctggtcca aaggactata gctaagcaga ttcagatggt gaaacagatt ggaaaaggtc gctatgggga agtttggatg ggaaagtggc gtggcgaaaa ggtagctgtg aaagtgttct tcaccacaga ggaagccagc tggttcagag agacagaaat atatcagaca gtgttgatga ggcatgaaaa cattttgggt ttcattgctg cagatatcaa agggacaggg tcctggaccc agttgtacct aatcacagac tatcatgaaa atggttccct ttatgattat ctgaagtcca ccaccctaga cgctaaatca atgctgaagt tagcctactc ttctgtcagt ggcttatgtc atttacacac agaaatcttt agtactcaag gcaaaccagc aattgcccat cgagatctga aaagtaaaaa cattctggtg aagaaaaatg gaacttgctg tattgctgac ctgggcctgg ctgttaaatt tattagtgat acaaatgaag ttgacatacc acctaacact cgagttggca ccaaacgcta tatgcctcca gaagtgttgg acgagagctt gaacagaaat cacttccagt cttacatcat ggctgacatg tatagttttg gcctcatcct ttgggaggtt gctaggagat gtgtatcagg aggtatagtg gaagaatacc agcttcctta tcatgaccta gtgcccagtg acccctctta tgaggacatg agggagattg tgtgcatcaa gaagttacgc ccctcattcc caaaccggtg gagcagtgat gagtgtctaa ggcagatggg aaaactcatg acagaatgct gggctcacaa tcctgcatca aggctgacag ccctgcgggt taagaaaaca cttgccaaaa tgtcagagtc ccaggacatt aaactctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of BMPR1B cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for BMPR1B. It may not necessarily be applicable to this product.
NCBI Accession #
BC047773
[Other Products]
UniProt Secondary Accession #
P78366; B2R953; B4DSV1[Other Products]
UniProt Related Accession #
O00238[Other Products]
Molecular Weight
60,582 Da
NCBI Official Full Name
Homo sapiens bone morphogenetic protein receptor, type IB, mRNA
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1B
NCBI Official Symbol
BMPR1B [Similar Products]
NCBI Official Synonym Symbols
ALK6; AMDD; BDA2; ALK-6; BDA1D; CDw293
[Similar Products]
NCBI Protein Information
bone morphogenetic protein receptor type-1B
UniProt Protein Name
Bone morphogenetic protein receptor type-1B
UniProt Synonym Protein Names
CD_antigen: CDw293
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR1B [Similar Products]
UniProt Synonym Gene Names
BMP type-1B receptor; BMPR-1B [Similar Products]
UniProt Entry Name
BMR1B_HUMAN
NCBI Summary for BMPR1B
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Comments for BMPR1B
BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.
Protein type: Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; Kinase, protein; Membrane protein, integral; TKL group; STKR family; Type1 subfamily
Chromosomal Location of Human Ortholog: 4q22-q24
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; glycoprotein binding; protein binding; protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity
Biological Process: BMP signaling pathway; chondrocyte development; eye development; limb morphogenesis; ovarian cumulus expansion; ovulation cycle; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of chondrocyte differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; proteoglycan biosynthetic process; skeletal development
Disease: Brachydactyly, Type A1, D; Brachydactyly, Type A2; Chondrodysplasia, Acromesomelic, With Genital Anomalies
Research Articles on BMPR1B
1. Two novel mutations in BMPR1B were identified in two patients with brachydactyly type A1.
Precautions
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Disclaimer
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