Product Name
aldehyde dehydrogenase 4 family, member A1 (ALDH4A1), Polyclonal Antibody
Full Product Name
Rabbit anti-human aldehyde dehydrogenase 4 family, member A1 polyclonal Antibody
Product Synonym Names
aldehyde dehydrogenase 4 family; member A1; ALDH4A1; ALDH4; P5CD; P5CDh; P5CDhL; P5CDhS
Product Gene Name
anti-ALDH4A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-69145 / sc-130948
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ALDH4A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ALDH4A1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for ALDH4A1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH23600.1
[Other Products]
UniProt Secondary Accession #
Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6; A8K1Q7; B4DGE4; D2D4A3[Other Products]
UniProt Related Accession #
P30038[Other Products]
Molecular Weight
56,043 Da[Similar Products]
NCBI Official Full Name
Aldehyde dehydrogenase 4 family, member A1
NCBI Official Synonym Full Names
aldehyde dehydrogenase 4 family, member A1
NCBI Official Symbol
ALDH4A1 [Similar Products]
NCBI Official Synonym Symbols
P5CD; ALDH4; P5CDh
[Similar Products]
NCBI Protein Information
delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase
UniProt Protein Name
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase
UniProt Gene Name
ALDH4A1 [Similar Products]
UniProt Synonym Gene Names
ALDH4; P5CDH; P5C dehydrogenase [Similar Products]
UniProt Entry Name
AL4A1_HUMAN
NCBI Summary for ALDH4A1
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for ALDH4A1
ALDH4A1: Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2). HP-2 is characterized by the accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologic manifestations, including seizures and mental retardation. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.2.1.88; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: mitochondrial matrix
Molecular Function: identical protein binding; aldehyde dehydrogenase (NAD) activity; electron carrier activity; 1-pyrroline-5-carboxylate dehydrogenase activity
Biological Process: 4-hydroxyproline catabolic process; proline catabolic process; proline biosynthetic process; glutamate biosynthetic process; proline catabolic process to glutamate; proline metabolic process
Disease: Hyperprolinemia, Type Ii
Research Articles on ALDH4A1
1. Missense mutation in ALDH4A1 is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability.
Precautions
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Disclaimer
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