Full Product Name
APC2 Antibody, Biotin Conjugated
Product Synonym Names
Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; APC2; APCL
Product Gene Name
anti-APC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95996
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-APC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-APC2 antibody
Cardiovascular
Applications Tested/Suitable for anti-APC2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for APC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005874.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005883.2
[Other Products]
UniProt Primary Accession #
O95996
[Other Products]
UniProt Secondary Accession #
Q05BW4; Q9UBZ1; Q9UEM8; Q9UQJ8; Q9UQJ9; Q9Y632[Other Products]
UniProt Related Accession #
O95996[Other Products]
Molecular Weight
213,799 Da
NCBI Official Full Name
adenomatous polyposis coli protein 2 isoform 1
NCBI Official Synonym Full Names
APC2, WNT signaling pathway regulator
NCBI Official Symbol
APC2 [Similar Products]
NCBI Official Synonym Symbols
APCL
[Similar Products]
NCBI Protein Information
adenomatous polyposis coli protein 2
UniProt Protein Name
Adenomatous polyposis coli protein 2
UniProt Synonym Protein Names
Adenomatous polyposis coli protein-like; APC-like
Protein Family
Acetophenone carboxylase
UniProt Gene Name
APC2 [Similar Products]
UniProt Synonym Gene Names
APCL; APC-like [Similar Products]
NCBI Summary for APC2
This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
UniProt Comments for APC2
Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).
Research Articles on APC2
1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains.
Precautions
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Disclaimer
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