Product Name
C1GALT1C1, Polyclonal Antibody
Full Product Name
C1GALT1C1 Antibody
Product Synonym Names
C1GALT2; C1Gal-T2; COSMC; HSPC067; MGC19947; c38h2-l1
Product Gene Name
anti-C1GALT1C1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of C1GALT1C1
Calculated Molecular Weight: 36kd
Observed Molecular Weight: 36kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-67482 / sc-68410
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-C1GALT1C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C1GALT1C1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-C1GALT1C1 antibody
WB: 1:500-1:5000
Testing Data of anti-C1GALT1C1 antibody
NCBI/Uniprot data below describe general gene information for C1GALT1C1. It may not necessarily be applicable to this product.
NCBI Accession #
Q96EU7.1
[Other Products]
UniProt Secondary Accession #
Q8WWS3; Q9NZX1; A8K246[Other Products]
UniProt Related Accession #
Q96EU7[Other Products]
Molecular Weight
36,382 Da
NCBI Official Full Name
C1GALT1-specific chaperone 1
NCBI Official Synonym Full Names
C1GALT1-specific chaperone 1
NCBI Official Symbol
C1GALT1C1 [Similar Products]
NCBI Official Synonym Symbols
TNPS; COSMC; MST143; C1GALT2; HSPC067; C38H2-L1
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NCBI Protein Information
C1GALT1-specific chaperone 1; C1Gal-T2; C38H2-like protein 1; beta 1,3-galactosyltransferase 2; core 1 beta1,3-galactosyltransferase 2; core 1 beta3-Gal-T2; core 1 beta3-galactosyltransferase-specific molecular chaperone
UniProt Protein Name
C1GALT1-specific chaperone 1
UniProt Synonym Protein Names
C38H2-like protein 1; C38H2-L1; Core 1 beta1,3-galactosyltransferase 2; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2; Core 1 beta3-galactosyltransferase-specific molecular chaperone
Protein Family
C1GALT1-specific chaperone
UniProt Gene Name
C1GALT1C1 [Similar Products]
UniProt Synonym Gene Names
COSMC; C38H2-L1; C1Gal-T2; C1GalT2; Core 1 beta3-Gal-T2 [Similar Products]
UniProt Entry Name
C1GLC_HUMAN
NCBI Summary for C1GALT1C1
This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]
UniProt Comments for C1GALT1C1
C1GALT1C1: Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). Defects in C1GALT1C1 are the cause of Tn syndrome (TNSYN). Tn syndrome is a rare autoimmune disease caused by somatic mutation in the C1GALT1C1 gene in which subpopulations of blood cells of all lineages carry an incompletely glycosylated membrane glycoprotein, i.e. the Tn antigen. Since leukocytes and platelets are affected as well as red cells, anemia, leukopenia and thrombocytopenia are features. Tn-polyagglutinability is sometimes associated with leukemia or is a preleukemic state. Belongs to the glycosyltransferase 31 family. Beta3- Gal-T subfamily.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: protein binding; polypeptide N-acetylgalactosaminyltransferase activity
Biological Process: platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; positive regulation of transferase activity; post-translational protein modification
Disease: Tn Polyagglutination Syndrome
Research Articles on C1GALT1C1
1. CBRT is a unique recognition motif for Cosmc to promote its regulation and formation of active T-synthase and represents the first sequence-specific chaperone recognition system in the ER/Golgi required for normal protein O-glycosylation
Precautions
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