Product Name
Desmocollin 2 (DSC2), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Desmocollin 2 (DSC2)
Product Synonym Names
ARVD11; CDHF2; DG2; DGII/III; Cadherin family member 2; Desmosomal glycoprotein III
Product Gene Name
anti-DSC2 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Desmocollin 2 (MBS2027335)
Biotin Conjugated Antibody: Desmocollin 2 (DSC2) (MBS2096186)
Matching Pairs
Biotin Conjugated Antibody: Desmocollin 2 (DSC2) (MBS2096186)
Immunogen: Desmocollin 2 (MBS2031086)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
DSC2 (Arg136~Cys471)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-DSC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DSC2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for DSC2. It may not necessarily be applicable to this product.
NCBI Accession #
AAH63291.1
[Other Products]
UniProt Related Accession #
Q02487[Other Products]
Molecular Weight
93,769 Da
NCBI Official Full Name
Desmocollin 2
NCBI Official Synonym Full Names
desmocollin 2
NCBI Official Symbol
DSC2 [Similar Products]
NCBI Official Synonym Symbols
DG2; DSC3; CDHF2; ARVD11; DGII/III
[Similar Products]
NCBI Protein Information
desmocollin-2
UniProt Protein Name
Desmocollin-2
UniProt Synonym Protein Names
Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
Protein Family
Desmocollin
UniProt Gene Name
DSC2 [Similar Products]
NCBI Summary for DSC2
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for DSC2
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Research Articles on DSC2
1. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
