ATP5G3, Antibody

ATP synthase lipid-binding protein,mitochondrial; ATP synthase proteolipid P3; ATPase protein 9

For Research Use Only. Not for use in diagnostic procedures.

ATP5G3 antibody detects endogenous levels of total ATP5G3 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-ATP5G3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:40000

Peptide-+

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human pancreas tissue using ATP5G3 antibody. Immunofluorescence analysis of A549 cells, using ATP5G3 antibody.

14,693 Da

ATP synthase membrane subunit c locus 3

ATP synthase F(0) complex subunit C3, mitochondrial

ATP synthase F(0) complex subunit C3, mitochondrial

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Yan W.L., Genomics 24:375-377(1994). L., Du H., Nature 434:724-731(2005). The MGC Project Team; Genome Res. 14:2121-2127(2004).

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