NIPA1, Polyclonal Antibody

FSP3; SPG6

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total NIPA1 protein.

Antigen affinity purification

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

0.7mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-NIPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1: 20-100

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using NIPA1 Antibody at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200)

27,310 Da

non imprinted in Prader-Willi/Angelman syndrome 1

magnesium transporter NIPA1

Magnesium transporter NIPA1

SPG6  [Similar Products]

NIPA1_HUMAN

This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008]

NIPA1: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6). Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Belongs to the NIPA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q11.2

Cellular Component: membrane; plasma membrane

Molecular Function: magnesium ion transmembrane transporter activity

Biological Process: magnesium ion transport; transmembrane transport

Disease: Spastic Paraplegia 6, Autosomal Dominant

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