Full Product Name
LETM1 Antibody, HRP conjugated
Product Synonym Names
Mitochondrial proton/calcium exchanger protein; Leucine zipper-EF-hand-containing transmembrane protein 1; LETM1
Product Gene Name
anti-LETM1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95202
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Mitochondrial proton/calcium exchanger protein (443-543AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-LETM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LETM1 antibody
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).
Product Categories/Family for anti-LETM1 antibody
Tags & Cell Markers; Metabolism
Applications Tested/Suitable for anti-LETM1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for LETM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036450.1
[Other Products]
NCBI GenBank Nucleotide #
NM_012318.2
[Other Products]
UniProt Primary Accession #
O95202
[Other Products]
UniProt Secondary Accession #
Q9UF65; B4DED2[Other Products]
UniProt Related Accession #
O95202[Other Products]
Molecular Weight
33,245 Da
NCBI Official Full Name
mitochondrial proton/calcium exchanger protein
NCBI Official Synonym Full Names
leucine zipper and EF-hand containing transmembrane protein 1
NCBI Official Symbol
LETM1 [Similar Products]
NCBI Official Synonym Symbols
SLC55A1
[Similar Products]
NCBI Protein Information
mitochondrial proton/calcium exchanger protein; LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Protein Name
Mitochondrial proton/calcium exchanger protein
UniProt Synonym Protein Names
Leucine zipper-EF-hand-containing transmembrane protein 1
Protein Family
LETM1 domain-containing protein
UniProt Gene Name
LETM1 [Similar Products]
NCBI Summary for LETM1
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
UniProt Comments for LETM1
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248).
Research Articles on LETM1
1. LETM1 plays an important role in the progression of breast cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
