LETM1, Blocking Peptide

LETM1 and EF-hand domain-containing protein 1; mitochondrial; Leucine zipper-EF-hand-containing transmembrane protein 1; LETM1

For Research Use Only. Not for use in diagnostic procedures.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of LETM1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization.

33,245 Da

leucine zipper and EF-hand containing transmembrane protein 1

LETM1 and EF-hand domain-containing protein 1, mitochondrial

LETM1 and EF-hand domain-containing protein 1, mitochondrial

LETM1_HUMAN

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

LETM1: Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Membrane protein, integral; Calcium-binding

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: mitochondrial inner membrane; mitochondrion

Molecular Function: protein binding

Biological Process: cristae formation

Disease: Wolf-hirschhorn Syndrome

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