Full Product Name
LETM1 Antibody (C-term)
Product Synonym Names
LETM1 and EF-hand domain-containing protein 1; mitochondrial; Leucine zipper-EF-hand-containing transmembrane protein 1; LETM1
Product Gene Name
anti-LETM1 antibody
[Similar Products]
Antibody/Peptide Pairs
LETM1 peptide (MBS9222583) is used for blocking the activity of LETM1 antibody (MBS9201351)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
577-607
3D Structure
ModBase 3D Structure for O95202
Specificity
This LETM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-607 amino acids from the C-terminal region of human LETM1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-LETM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LETM1 antibody
This gene encodes a protein that is localized to the inner
mitochondrial membrane. The protein functions to maintain the
mitochondrial tubular shapes and is required for normal
mitochondrial morphology and cellular viability. Mutations in this
gene cause Wolf-Hirschhorn syndrome, a complex malformation
syndrome caused by the deletion of parts of the distal short arm of
chromosome 4. Related pseudogenes have been identified on
chromosomes 8, 15 and 19.
Product Categories/Family for anti-LETM1 antibody
Metabolism
Applications Tested/Suitable for anti-LETM1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-LETM1 antibody
WB~~1:1000
Western Blot (WB) of anti-LETM1 antibody
LETM1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the LETM1 antibody detected the LETM1 protein (arrow).
NCBI/Uniprot data below describe general gene information for LETM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036450.1
[Other Products]
NCBI GenBank Nucleotide #
NM_012318.2
[Other Products]
UniProt Primary Accession #
O95202
[Other Products]
UniProt Secondary Accession #
Q9UF65; B4DED2[Other Products]
UniProt Related Accession #
O95202[Other Products]
NCBI Official Full Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial
NCBI Official Synonym Full Names
leucine zipper-EF-hand containing transmembrane protein 1
NCBI Official Symbol
LETM1 [Similar Products]
NCBI Protein Information
LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Protein Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Synonym Protein Names
Leucine zipper-EF-hand-containing transmembrane protein 1
Protein Family
LETM1 domain-containing protein
UniProt Gene Name
LETM1 [Similar Products]
UniProt Entry Name
LETM1_HUMAN
NCBI Summary for LETM1
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
UniProt Comments for LETM1
LETM1: Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane
Molecular Function: protein binding; calcium ion binding
Biological Process: cristae formation
Disease: Wolf-hirschhorn Syndrome
Product References and Citations for anti-LETM1 antibody
Jiang, D., et al. Science 326(5949):144-147(2009)
Piao, L., et al. Cell. Signal. 21(5):767-777(2009)
Piao, L., et al. Cancer Res. 69(8):3397-3404(2009)
Tamai, S., et al. J. Cell. Sci. 121 (PT 15), 2588-2600 (2008) :
Dimmer, K.S., et al. Hum. Mol. Genet. 17(2):201-214(2008)
Research Articles on LETM1
1. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.
Precautions
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Disclaimer
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