Product Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial, Recombinant Protein
Full Product Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial
Product Gene Name
LETM1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
116-739. Full-Length of Mature Protein
Sequence
DDSVVEKSLK SLKDKNKKLE EGGPVYSPPA EVVVKKSLGQ RVLDELKHYY HGFRLLWIDT KIAARMLWRI LNGHSLTRRE RRQFLRICAD LFRLVPFLVF VVVPFMEFLL PVAVKLFPNM LPSTFETQSL KEERLKKELR VKLELAKFLQ DTIEEMALKN KAAKGSATKD FSVFFQKIRE TGERPSNEEI MRFSKLFEDE LTLDNLTRPQ LVALCKLLEL QSIGTNNFLR FQLTMRLRSI KADDKLIAEE GVDSLNVKEL QAACRARGMR ALGVTEDRLR GQLKQWLDLH LHQEIPTSLL ILSRAMYLPD TLSPADQLKS TLQTLPEIVA KEAQVKVAEV EGEQVDNKAK LEATLQEEAA IQQEHREKEL QKRSEVAKDF EPERVVAAPQ RPGTEPQPEM PDTVLQSETL KDTAPVLEGL KEEEITKEEI DILSDACSKL QEQKKSLTKE KEELELLKED VQDYSEDLQE IKKELSKTGE EKYVEESKAS KRLTKRVQQM IGQIDGLISQ LEMDQQAGKL APANGMPTGE NVISVAELIN AMKQVKHIPE SKLTSLAAAL DENKDGKVNI DDLVKVIELV DKEDVHISTS QVAEIVATLE KEEKVEEKEK AKEKAEKEVA EVKS
3D Structure
ModBase 3D Structure for O95202
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of LETM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LETM1 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for LETM1 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for LETM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036450.1
[Other Products]
NCBI GenBank Nucleotide #
NM_012318.2
[Other Products]
UniProt Primary Accession #
O95202
[Other Products]
UniProt Secondary Accession #
Q9UF65; B4DED2[Other Products]
UniProt Related Accession #
O95202[Other Products]
Molecular Weight
33,245 Da
NCBI Official Full Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial
NCBI Official Synonym Full Names
leucine zipper and EF-hand containing transmembrane protein 1
NCBI Official Symbol
LETM1 [Similar Products]
NCBI Protein Information
LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Protein Name
LETM1 and EF-hand domain-containing protein 1, mitochondrial
UniProt Synonym Protein Names
Leucine zipper-EF-hand-containing transmembrane protein 1
Protein Family
LETM1 and EF-hand domain-containing protein
UniProt Gene Name
LETM1 [Similar Products]
UniProt Entry Name
LETM1_HUMAN
NCBI Summary for LETM1
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
UniProt Comments for LETM1
LETM1: Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Calcium-binding; Mitochondrial
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: mitochondrial inner membrane; mitochondrion
Molecular Function: protein binding
Biological Process: cristae formation
Disease: Wolf-hirschhorn Syndrome
Research Articles on LETM1
1. LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
