BMPR1B, Polyclonal Antibody

Anti -BMPR1B, NT (D17) (Bone Morphogenetic Protein Receptor Type-1B, BMP Type-1B Receptor, BMPR-1B, CDw293)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000004.11 (95679128..96079601). Location: 4q22-q24

Polyclonal

IgG

Rabbit

Recognizes human BMPR1B. Species Crossreactivity: mouse.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-BMPR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55kD and type II receptors of about 70-80kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Antibodies; Abs to Receptors

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

bone morphogenetic protein receptor, type IB

bone morphogenetic protein receptor type-1B; BMPR-1B; OTTHUMP00000161621; OTTHUMP00000161622; OTTHUMP00000219359; OTTHUMP00000219880; OTTHUMP00000219882; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase

Bone morphogenetic protein receptor type-1B

BMR1B_HUMAN

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Kinase, protein; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; limb morphogenesis; protein amino acid phosphorylation; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; dorsal/ventral pattern formation; eye development; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; positive regulation of cell differentiation; inflammatory response; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Chondrodysplasia, Acromesomelic, With Genital Anomalies; Brachydactyly, Type A2

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