Full Product Name
Anti-CHRNG Antibody
Product Gene Name
anti-CHRNG antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human CHRNG
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CHRNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHRNG antibody
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in ***** skeletal muscle) or gamma (in fetal and denervated muscle) subunit.
Applications Tested/Suitable for anti-CHRNG antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CHRNG antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for CHRNG. It may not necessarily be applicable to this product.
NCBI Accession #
AAI11803.1
[Other Products]
UniProt Secondary Accession #
Q14DU4; Q53RG2; B3KWM8[Other Products]
UniProt Related Accession #
P07510[Other Products]
Molecular Weight
52,020 Da
NCBI Official Full Name
CHRNG protein
NCBI Official Synonym Full Names
cholinergic receptor nicotinic gamma subunit
NCBI Official Symbol
CHRNG [Similar Products]
NCBI Official Synonym Symbols
ACHRG
[Similar Products]
NCBI Protein Information
acetylcholine receptor subunit gamma
UniProt Protein Name
Acetylcholine receptor subunit gamma
Protein Family
Acetylcholine receptor
UniProt Gene Name
CHRNG [Similar Products]
UniProt Synonym Gene Names
ACHRG [Similar Products]
NCBI Summary for CHRNG
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in ***** skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
UniProt Comments for CHRNG
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Research Articles on CHRNG
1. CHRNG mutations associated with interfamilial variability of the severity of the Escobar variant of multiple pterygium syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
