GYS2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

2.4mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-GYS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content.

ELISA (EIA), Immunohistochemistry (IHC)

IHC: 1:100-1:300

Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using GYS2 Polyclonal Antibody at dilution 1:50

Immunohistochemistry of paraffin-embedded Human brain tissue using GYS2 Polyclonal Antibody at dilution 1:50

80,989 Da

glycogen synthase 2 (liver)

glycogen [starch] synthase, liver; glycogen [starch] synthase, liver

Glycogen [starch] synthase, liver

GYS2_HUMAN

The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]

GYS2: Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0); A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. Belongs to the glycosyltransferase 3 family.

Protein type: Transferase; EC 2.4.1.11; Carbohydrate Metabolism - starch and sucrose; Cytoskeletal

Chromosomal Location of Human Ortholog: 12p12.2

Cellular Component: cortical actin cytoskeleton; cytoskeleton; ectoplasm; cytoplasm; cell cortex; cytosol

Molecular Function: protein homodimerization activity; glycogen (starch) synthase activity

Biological Process: generation of precursor metabolites and energy; glycogen biosynthetic process; carbohydrate metabolic process; response to glucose stimulus; glucose metabolic process; pathogenesis

Disease: Glycogen Storage Disease 0, Liver

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