Product Name
GYS2, cDNA Clone
Full Product Name
GYS2 cDNA Clone
Product Gene Name
GYS2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcttcgag gccgatccct ctctgtaaca tccctgggtg ggcttcccca gtgggaagtc gaagaacttc ctgtggagga gttactgctc tttgaagttg cttgggaagt gaccaataaa gttggaggca tctatactgt gattcagaca aaggccaaaa caacagcaga tgaatgggga gagaactatt ttctgatagg tccatatttt gagcataata tgaagactca ggtggaacag tgtgaacctg taaatgatgc tgtcagaaga gcagtggacg caatgaataa gcatggctgc caggtgcatt ttggaagatg gctgatagaa ggaagtcctt atgtggtact ttttgacata ggctattcag cttggaatct ggacaggtgg aagggtgacc tctgggaagc atgcagtgtc ggcattcctt atcatgaccg agaagccaat gatatgctga tatttggatc tttaactgcc tggttcttaa aagaggtgac agatcatgca gatggtaaat atgtcgttgc ccaattccat gaatggcagg ctggaattgg actgatcctt tctcgagcca ggaaacttcc tattgccaca atatttacaa cccacgctac actacttggg aggtatctct gtgcagcaaa tattgatttc tacaaccatc ttgataagtt taacattgac aaagaggctg gggaaaggca gatttaccac cggtactgca tggagcgagc ttccgttcat tgcgctcacg tgttcaccac ggtttctgaa ataacagcaa tagaagctga acatatgctg aagagaaagc ctgatgtagt tactccaaac ggcttgaatg ttaagaaatt ttcagcagtg catgagtttc aaaatctaca tgccatgtac aaggccagaa tccaagattt tgttcgaggt catttctatg gtcatctcga ctttgatctt gaaaagactt tgttcctttt cattgctggg aggtatgagt tttcaaacaa aggagctgac atcttcctag aatccttatc caggctaaat ttcctgctga ggatgcataa aagtgacatc acagtggtgg tgtttttcat tatgcctgcc aagacaaata atttcaacgt ggaaaccctg aaaggacaag cagtgcgaaa acagctgtgg gatgttgcac attctgtgaa ggaaaagttt ggaaaaaaac tctatgatgc attattaaga ggagaaattc ctgacctgaa cgatatttta gatcgagatg atctaacaat tatgaaaaga gccatctttt caactcagcg acagtcattg cccccagtga ccacgcacaa catgattgat gactccaccg accccatcct cagcaccatt agacggattg gacttttcaa caaccgcaca gatagagtca aggtgatttt gcacccagag tttctatcct ccaccagtcc cttactaccc atggactatg aagagtttgt tagaggttgt catcttggag tatttccatc atactatgaa ccctggggtt atactccagc tgaatgcact gtgatgggta tccccagtgt gaccacgaat ctctccgggt ttggctgttt catgcaggag cacgtggctg atcctactgc ttacggtatt tacatcgttg acaggcggtt ccgttctcca gatgattctt gcaatcagct gactaagttt ctctatggat tttgcaaaca gtcacgccgc caaaggatta tccagaggaa cagaactgag aggctctcag atcttctgga ttggagatac ttaggcagat attaccagca tgccagacac ctgacattaa gcagagcttt tccagataaa ttccatgtgg aactaacatc accaccaacg acagaaggat ttaaatatcc caggccttcc tcagtaccac cttctccttc agggtctcag gcctccagtc ctcagagcag tgatgtggaa gatgaagtgg aggatgagag atacgatgag gaagaggagg ctgaaaggga tcggttaaat atcaagtcac cattttcact gagccacgtt cctcatggga agaaaaagct gcatggtgaa tataagaact ga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GYS2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GYS2. It may not necessarily be applicable to this product.
NCBI Accession #
BC126310
[Other Products]
UniProt Secondary Accession #
A0AVD8[Other Products]
UniProt Related Accession #
P54840[Other Products]
Molecular Weight
80,989 Da
NCBI Official Full Name
Homo sapiens glycogen synthase 2 (liver), mRNA
NCBI Official Synonym Full Names
glycogen synthase 2
NCBI Official Symbol
GYS2 [Similar Products]
NCBI Protein Information
glycogen [starch] synthase, liver
UniProt Protein Name
Glycogen [starch] synthase, liver
Protein Family
Glycogen [starch] synthase
UniProt Gene Name
GYS2 [Similar Products]
UniProt Entry Name
GYS2_HUMAN
NCBI Summary for GYS2
The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]
UniProt Comments for GYS2
GYS2: Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0); A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. Belongs to the glycosyltransferase 3 family.
Protein type: Cytoskeletal; Transferase; Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11
Chromosomal Location of Human Ortholog: 12p12.2
Cellular Component: cell cortex; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; ectoplasm
Molecular Function: glycogen (starch) synthase activity; protein homodimerization activity
Biological Process: generation of precursor metabolites and energy; glycogen biosynthetic process; response to glucose stimulus
Disease: Glycogen Storage Disease 0, Liver
Research Articles on GYS2
1. Sequencing of the GYS2 gene is more likely to be positive in patients with fasting ketotic hypoglycaemia and concomitant postprandial hyperglycaemia with hyperlactataemia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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