Full Product Name
ABCC2 Antibody
Product Synonym Names
Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2; ABCC2; CMOAT; CMOAT1; CMRP; MRP2
Product Gene Name
anti-ABCC2 antibody
[Similar Products]
Product Synonym Gene Name
MRP2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92887
Specificity
ABCC2 Antibody detects endogenous levels of ABCC2.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ABCC2.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ABCC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCC2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCC2 antibody
WB: 1:500~1:1000
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for ABCC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000383.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000392.4
[Other Products]
UniProt Primary Accession #
Q92887
[Other Products]
UniProt Secondary Accession #
Q14022; Q5T2B1; Q92500; Q92798; Q99663; Q9UMS2; B2RMT8[Other Products]
UniProt Related Accession #
Q92887[Other Products]
NCBI Official Full Name
canalicular multispecific organic anion transporter 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 2
NCBI Official Symbol
ABCC2 [Similar Products]
NCBI Official Synonym Symbols
DJS; MRP2; cMRP; ABC30; CMOAT
[Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 1
UniProt Protein Name
Canalicular multispecific organic anion transporter 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC2 [Similar Products]
UniProt Synonym Gene Names
CMOAT; CMOAT1; CMRP; MRP2 [Similar Products]
NCBI Summary for ABCC2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC2
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Research Articles on ABCC2
1. Self-inhibition of the MRP2-dependent secretion of MTX is a plausible explanation for the time-dependent PKs of this drug.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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