ARALAR1, Polyclonal Antibody

Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12; SLC25A12; ARALAR1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified Rabbit Polyclonal Antibody (Pab)

0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%

1mg/ml (lot specific)

Store at -20 degree C.Stable for 12 months from date of receipt

Small volumes of anti-SLC25A12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.

Metabolism; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)-Paraffin

WB~~ 1:1000

All lanes : Anti-ARALAR1 Antibody at 1:1000 dilution
Lane 1: human skeletal muscle lysates
Lane 2: human heart lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 75 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

74762

solute carrier family 25 (aspartate/glutamate carrier), member 12

calcium-binding mitochondrial carrier protein Aralar1

Calcium-binding mitochondrial carrier protein Aralar1

ARALAR1  [Similar Products]

CMC1_HUMAN

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

SLC25A12: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Defects in SLC25A12 are the cause of global cerebral hypomyelination (GCHM). A disorder with onset in infancy and characterized by severe psychomotor retardation, hypotonia, seizures, hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Belongs to the mitochondrial carrier family.

Protein type: Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: L-aspartate transmembrane transporter activity; calcium ion binding; L-glutamate transmembrane transporter activity

Biological Process: L-glutamate transport; carbohydrate metabolic process; glucose metabolic process; pathogenesis; aspartate transport; response to calcium ion; malate-aspartate shuttle; gluconeogenesis

Disease: Hypomyelination, Global Cerebral

Del Arco A.,et al.J. Biol. Chem. 273:23327-23334(1998).
Palmieri L.,et al.EMBO J. 20:5060-5069(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kobayashi K.,et al.Nat. Genet. 22:159-163(1999).

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.