Full Product Name
ABCC2 Antibody, HRP conjugated
Product Synonym Names
Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2; ABCC2; CMOAT; CMOAT1; CMRP; MRP2
Product Gene Name
anti-ABCC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92887
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Canalicular multispecific organic anion transporter 1 protein (724-947AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ABCC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC2 antibody
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Product Categories/Family for anti-ABCC2 antibody
Cancer; Metabolism; Signal transduction
Applications Tested/Suitable for anti-ABCC2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ABCC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000383.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000392.4
[Other Products]
UniProt Primary Accession #
Q92887
[Other Products]
UniProt Secondary Accession #
Q14022; Q5T2B1; Q92500; Q92798; Q99663; Q9UMS2; B2RMT8[Other Products]
UniProt Related Accession #
Q92887[Other Products]
Molecular Weight
174,207 Da
NCBI Official Full Name
canalicular multispecific organic anion transporter 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 2
NCBI Official Symbol
ABCC2 [Similar Products]
NCBI Official Synonym Symbols
DJS; MRP2; cMRP; ABC30; CMOAT
[Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 1
UniProt Protein Name
Canalicular multispecific organic anion transporter 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC2 [Similar Products]
UniProt Synonym Gene Names
CMOAT; CMOAT1; CMRP; MRP2 [Similar Products]
NCBI Summary for ABCC2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC2
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Research Articles on ABCC2
1. Self-inhibition of the MRP2-dependent secretion of MTX is a plausible explanation for the time-dependent PKs of this drug.
Precautions
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Disclaimer
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