Full Product Name
CHRNG Antibody
Product Synonym Names
Acetylcholine receptor subunit gamma; CHRNG; ACHRG
Product Gene Name
anti-CHRNG antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07510
Purity/Purification
Antigen Affinity Purified
Immunogen
Recombinant human Acetylcholine receptor subunit gamma protein (C-190AA)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1453 / sc-13998
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CHRNG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHRNG antibody
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Applications Tested/Suitable for anti-CHRNG antibody
ELISA (EIA), Western Blot (WB)
Western Blot (WB) of anti-CHRNG antibody
Western blot
All lanes: CHRNG antibody at 5.5ug/ml
Lane 1: 293T whole cell lysate
Lane 2: HepG-2 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58,53 kDa
Observed band size: 58 kDa
NCBI/Uniprot data below describe general gene information for CHRNG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005190.4
[Other Products]
NCBI GenBank Nucleotide #
NM_005199.4
[Other Products]
UniProt Primary Accession #
P07510
[Other Products]
UniProt Secondary Accession #
Q14DU4; Q53RG2; B3KWM8[Other Products]
Molecular Weight
52,020 Da
NCBI Official Full Name
acetylcholine receptor subunit gamma
UniProt Protein Name
Acetylcholine receptor subunit gamma
Protein Family
Acetylcholine receptor
UniProt Gene Name
CHRNG [Similar Products]
UniProt Synonym Gene Names
ACHRG [Similar Products]
UniProt Entry Name
ACHG_HUMAN
UniProt Comments for CHRNG
nAChRG: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNG are a cause of multiple pterygium syndrome lethal type (MUPSL). Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent. Defects in CHRNG are a cause of multiple pterygium syndrome Escobar variant (MUPSE); also known as nonlethal type multiple pterygium syndrome. Escobar syndrome is a non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. is a. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: integral to plasma membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane
Molecular Function: acetylcholine binding; acetylcholine receptor activity; channel activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; protein binding
Biological Process: muscle contraction; neuromuscular synaptic transmission; response to nicotine; signal transduction; synaptic transmission, cholinergic; transport
Disease: Multiple Pterygium Syndrome, Escobar Variant; Multiple Pterygium Syndrome, Lethal Type
Precautions
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