CHRNG, Polyclonal Antibody

Western blot analysis of extracts from Mouse muscle, using CHRNG Ab. Lane 1 was treated with the blocking peptide.

Western blot analysis of extracts from HepG2, using CHRNG Ab.

Western blot analysis of CHRNG using HT29 whole cell lysates

MBS9609461 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the Ab for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit Ab was used as the secondary.

Observed: 58 kDa
Predicted: 58 kDa

cholinergic receptor nicotinic gamma subunit

acetylcholine receptor subunit gamma

Acetylcholine receptor subunit gamma

ACHRG  [Similar Products]

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in ***** skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

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