Product Name
Medium-wave-sensitive opsin 1 (Opn1mw), Recombinant Protein
Full Product Name
Recombinant Rat Medium-wave-sensitive opsin 1 (Opn1mw)
Product Gene Name
Opn1mw recombinant protein
[Similar Products]
Product Synonym Gene Name
Gcp[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-359aa; full length protein
Sequence
MAQQLTGEQT LDHYEDSTQA SIFTYTNSNS TRGPFEGPNY HIAPRWVYHL TSTWMILVVI ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAVWTA PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS LPSYFAKSAT IYNPIIYVFM NRQFRNCILQ LFGKKVDDSS ELSSTSKTEV SSVSSVSPA
3D Structure
ModBase 3D Structure for O35476
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Opn1mw recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Opn1mw recombinant protein
Transmembrane Protein
Application Notes for Opn1mw recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Opn1mw. It may not necessarily be applicable to this product.
NCBI Accession #
NP_446000.1
[Other Products]
NCBI GenBank Nucleotide #
NM_053548.1
[Other Products]
UniProt Primary Accession #
O35476
[Other Products]
UniProt Related Accession #
O35476[Other Products]
Molecular Weight
40,200 Da
NCBI Official Full Name
medium-wave-sensitive opsin 1
NCBI Official Synonym Full Names
opsin 1 (cone pigments), medium-wave-sensitive
NCBI Official Symbol
Opn1mw [Similar Products]
NCBI Protein Information
medium-wave-sensitive opsin 1
UniProt Protein Name
Medium-wave-sensitive opsin 1
UniProt Synonym Protein Names
Green cone photoreceptor pigment; Green-sensitive opsin; Medium wavelength-sensitive cone opsin
Protein Family
Medium-wave-sensitive opsin
UniProt Gene Name
Opn1mw [Similar Products]
UniProt Synonym Gene Names
Gcp [Similar Products]
UniProt Entry Name
OPSG_RAT
NCBI Summary for Opn1mw
a green visual pigment fo the retina; involved in color vision [RGD, Feb 2006]
UniProt Comments for Opn1mw
OPN1MW: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD); also known as deuteranopia. Defects in OPN1MW are a cause of blue cone monochromacy (BCM). A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5). A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1
Cellular Component: integral to plasma membrane; photoreceptor outer segment; plasma membrane
Molecular Function: G-protein coupled photoreceptor activity; photoreceptor activity
Biological Process: detection of visible light; G-protein coupled receptor protein signaling pathway; phototransduction; positive regulation of cytokinesis; protein-chromophore linkage; visual perception
Research Articles on Opn1mw
1. The deficiency in vision of the Opn1mw rat is similar to the color vision defects that occur in humans with a color vision defect but without recessive retinal degeneration.
Precautions
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Disclaimer
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