PDE6C, Polyclonal Antibody

cGMP phosphodiesterase 6C; COD4; PDE 6C; PDE6 alpha prime; PDEA2; Phosphodiesterase 6C cGMP specific cone alpha prime antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

BIOTIN-Conjugated

0.50-0.75 ug/ul in antibody stabilization buffer (lot specific)

-20 degree C for long term storage

Small volumes of anti-PDE6C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

BIOTIN-Conjugated cone cGMP phosphodiesterase Antibody
Guanosine 3', 5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

99,147 Da

phosphodiesterase 6C

cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

PDEA2  [Similar Products]

PDE6C_HUMAN

This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]

PDE6C: Defects in PDE6C are the cause of cone dystrophy type 4 (COD4). An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the cyclic nucleotide phosphodiesterase family.

Protein type: Phosphodiesterase; EC 3.1.4.35

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: plasma membrane

Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; metal ion binding

Biological Process: metabolic process; phototransduction, visible light; retinal cone cell development; visual perception

Disease: Cone Dystrophy 4

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