Full Product Name
PDE6C Antibody
Product Synonym Names
Cone cGMP-specific 3'; 5'-cyclic phosphodiesterase subunit alpha'; cGMP phosphodiesterase 6C; PDE6C; PDEA2
Product Gene Name
anti-PDE6C antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51160
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Cone cGMP-specific 3', 5'-cyclic phosphodiesterase subunit alpha' protein (285-451AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PDE6C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PDE6C antibody
visual perception
Product Categories/Family for anti-PDE6C antibody
Neuroscience; Signal transduction
Applications Tested/Suitable for anti-PDE6C antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-PDE6C antibody
WB: 1:500-1:5000
IF: 1:50-1:200
Western Blot (WB) of anti-PDE6C antibody
Western Blot
Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate
All lanes: PDE6C antibody at 3.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 100 KDa
Observed band size: 100 KDa
Immunofluorescence (IF) of anti-PDE6C antibody
Immunofluorescence staining of A549 cells with MBS7110063 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
NCBI/Uniprot data below describe general gene information for PDE6C. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006195.3
[Other Products]
NCBI GenBank Nucleotide #
NM_006204.3
[Other Products]
UniProt Primary Accession #
P51160
[Other Products]
UniProt Secondary Accession #
Q5VY29; A6NCR6[Other Products]
UniProt Related Accession #
P51160[Other Products]
Molecular Weight
99,147 Da
NCBI Official Full Name
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
NCBI Official Synonym Full Names
phosphodiesterase 6C
NCBI Official Symbol
PDE6C [Similar Products]
NCBI Official Synonym Symbols
COD4; ACHM5; PDEA2
[Similar Products]
NCBI Protein Information
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
UniProt Protein Name
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
UniProt Synonym Protein Names
cGMP phosphodiesterase 6C
Protein Family
Cone cGMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE6C [Similar Products]
UniProt Synonym Gene Names
PDEA2 [Similar Products]
NCBI Summary for PDE6C
This gene encodes the alpha-prime subunit of cone phosphodiesterase, which is composed of a homodimer of two alpha-prime subunits and 3 smaller proteins of 11, 13, and 15 kDa. Mutations in this gene are associated with cone dystrophy type 4 (COD4). [provided by RefSeq, Mar 2010]
UniProt Comments for PDE6C
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
Research Articles on PDE6C
1. A novel homozygous PDE6C mutation was identified as the cause of ACHM. In addition, we identified an OPN1SW mutation in the sibling with complete achromatopsia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
