Malonyl Coenzyme A Decarboxylase (MLYCD), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of MLYCD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2601228 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Malonyl Coenzyme A Decarboxylase (MLYCD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MLYCD. The ELISA analytical biochemical technique of the MBS2601228 kit is based on MLYCD antibody-MLYCD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MLYCD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MLYCD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

50,946 Da

malonyl-CoA decarboxylase

malonyl-CoA decarboxylase, mitochondrial; malonyl coenzyme A decarboxylase

Malonyl-CoA decarboxylase, mitochondrial

MCD  [Similar Products]

DCMC_HUMAN

The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]

MLYCD: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency). MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria.

Protein type: Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Other Amino Acids Metabolism - beta-alanine; Lyase

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: peroxisomal matrix; mitochondrion; mitochondrial matrix; cytoplasm; peroxisome

Molecular Function: receptor binding; malonyl-CoA decarboxylase activity

Biological Process: positive regulation of fatty acid oxidation; acetyl-CoA biosynthetic process; cellular lipid metabolic process; fatty acid biosynthetic process

Disease: Malonyl-coa Decarboxylase Deficiency

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