Full Product Name
MEFV Antibody, HRP conjugated
Product Synonym Names
Pyrin; Marenostrin; MEFV; MEF; TRIM201 Publication
Product Gene Name
anti-MEFV antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15553
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Pyrin protein (268-374AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MEFV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEFV antibody
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).
Product Categories/Family for anti-MEFV antibody
Immunology; Signal transduction
Applications Tested/Suitable for anti-MEFV antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MEFV. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000234.1
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NCBI GenBank Nucleotide #
NM_000243.2
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UniProt Primary Accession #
O15553
[Other Products]
UniProt Secondary Accession #
Q3MJ84; Q96PN4; Q96PN5; D3DUC0; F5H0Q3[Other Products]
UniProt Related Accession #
O15553[Other Products]
Molecular Weight
50,837 Da
NCBI Official Full Name
pyrin isoform 1
NCBI Official Synonym Full Names
MEFV, pyrin innate immunity regulator
NCBI Official Symbol
MEFV [Similar Products]
NCBI Official Synonym Symbols
FMF; MEF; TRIM20
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NCBI Protein Information
pyrin
UniProt Protein Name
Pyrin
UniProt Synonym Protein Names
Marenostrin
UniProt Gene Name
MEFV [Similar Products]
UniProt Synonym Gene Names
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NCBI Summary for MEFV
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for MEFV
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).
Research Articles on MEFV
1. The mutations of p.R42W, p.L110P, p.E148Q, p.R202Q, p.E230K, p.369PS, and p.R408Q, which have been reported in many Familial Mediterranean Fever patients, had significant allele frequency differences with the disease-causing mutations.
Precautions
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