Product Name
ATP13A2, Blocking Peptide
Full Product Name
ATP13A2 Antibody (C-term) Blocking Peptide
Product Synonym Names
Probable cation-transporting ATPase 13A2; 363-; ATP13A2; PARK9
Product Gene Name
ATP13A2 blocking peptide
[Similar Products]
Product Synonym Gene Name
PARK9[Similar Products]
Antibody/Peptide Pairs
ATP13A2 peptide (MBS9221919) is used for blocking the activity of ATP13A2 antibody (MBS9203648)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NQ11
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Multi-pass membrane protein. Lysosome
Tissue Location
Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons (at protein level)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ATP13A2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ATP13A2 blocking peptide
May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity.
NCBI/Uniprot data below describe general gene information for ATP13A2. It may not necessarily be applicable to this product.
NCBI Accession #
Q9NQ11.2
[Other Products]
UniProt Primary Accession #
Q9NQ11
[Other Products]
UniProt Secondary Accession #
O75700; Q5JXY1; Q5JXY2; Q6S9Z9[Other Products]
UniProt Related Accession #
Q9NQ11[Other Products]
Molecular Weight
128,323 Da
NCBI Official Full Name
Probable cation-transporting ATPase 13A2
NCBI Official Synonym Full Names
ATPase 13A2
NCBI Official Symbol
ATP13A2 [Similar Products]
NCBI Official Synonym Symbols
CLN12; KRPPD; PARK9; HSA9947
[Similar Products]
NCBI Protein Information
probable cation-transporting ATPase 13A2
UniProt Protein Name
Probable cation-transporting ATPase 13A2
Protein Family
Probable cation-transporting ATPase
UniProt Gene Name
ATP13A2 [Similar Products]
UniProt Synonym Gene Names
PARK9 [Similar Products]
UniProt Entry Name
AT132_HUMAN
NCBI Summary for ATP13A2
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Comments for ATP13A2
ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter, ion channel; EC 3.6.3.-; Transporter; Hydrolase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: autophagic vacuole; cell soma; integral to plasma membrane; late endosome; lysosomal lumen; lysosomal membrane; lysosome; multivesicular body; neuron projection; transport vesicle; vesicle
Molecular Function: cation-transporting ATPase activity; manganese ion binding; protein binding; zinc ion binding
Biological Process: cellular calcium ion homeostasis; cellular cation homeostasis; cellular iron ion homeostasis; cellular zinc ion homeostasis; positive regulation of protein secretion; protein amino acid autophosphorylation; regulation of autophagic vacuole size; regulation of endopeptidase activity; regulation of macroautophagy; zinc ion homeostasis
Disease: Kufor-rakeb Syndrome
Research Articles on ATP13A2
1. tre results of this study suggests that the expression of ATP13A2 regulated by the PHD2-HIF1alpha signaling pathway,and this is instrumental in maintaining cellular iron homeostasis and cell viability in mitochondrially compromised DAergic neurons.
Precautions
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