Product Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C (GCNT2), Recombinant Protein
Full Product Name
Recombinant Human N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C (GCNT2), partial
Product Gene Name
GCNT2 recombinant protein
[Similar Products]
Product Synonym Gene Name
GCNT2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MNFWRYCFFA FTLLSVVIFV RFYSSQLSPP KSYEKLNSSS ERYFRKTACN HALEKMPVFL WENILPSPLR SVPCKDYLTQ NHYITSPLSE EEAAFPLAYV MVIHKDFDTF ERLFRAIYMP QNVYCVHVDE KAPAEYKESV RQLLSCFQNA FIASKTESVV YAGISRLQAD LNCLKDLVAS EVPWKYVINT CGQDFPLKTN REIVQHLKGF KGKNITPGVL PPDHAIKRTK YVHQEHTDKG GFFVKNTNIL KTSPPHQLTI YFGTAYVALT RDFVDFVLRD QRAIDLLQWS KDTYSPDEHF WVTLNRVSGV PGSMPNASWT GNLRAIKWSD MEDRHGGCHG HYVHGICIYG NGDLKWLVNS PSLFANKFEL NTYPLTVECL ELRHRERTLN QSETAIQPSW YF
3D Structure
ModBase 3D Structure for Q8NFS9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GCNT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GCNT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001482.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001491.2
[Other Products]
UniProt Primary Accession #
Q8NFS9
[Other Products]
UniProt Secondary Accession #
Q06430; Q5T4J1; Q5W0E9; Q6T5E5; Q8NFS9[Other Products]
UniProt Related Accession #
Q8N0V5[Other Products]
Molecular Weight
46,531 Da
NCBI Official Full Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B
NCBI Official Synonym Full Names
glucosaminyl (N-acetyl) transferase 2 (I blood group)
NCBI Official Symbol
GCNT2 [Similar Products]
NCBI Official Synonym Symbols
II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2
[Similar Products]
NCBI Protein Information
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Protein Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Synonym Protein Names
I-branching enzyme; IGNT
Protein Family
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
UniProt Gene Name
GCNT2 [Similar Products]
UniProt Synonym Gene Names
GCNT5; II; NACGT1; N-acetylglucosaminyltransferase [Similar Products]
NCBI Summary for GCNT2
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to ***** I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with ***** i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for GCNT2
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.
Research Articles on GCNT2
1. miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
