Full Product Name
SLC16A2 Antibody
Product Synonym Names
Monocarboxylate transporter 8; MCT 8; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter
Product Gene Name
anti-SLC16A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P36021
Species Reactivity
Human, Mouse, Rat
Specificity
SLC16A2 antibody detects endogenous levels of total SLC16A2 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human SLC16A2.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-SLC16A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SLC16A2 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-SLC16A2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC16A2 antibody
WB: 1:500~1:1000
ELISA: 1:40000
Western Blot (WB) of anti-SLC16A2 antibody
Western blot analysis of extracts from K562 cells, using SLC16A2 antibody.
NCBI/Uniprot data below describe general gene information for SLC16A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006508.2
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NCBI GenBank Nucleotide #
NM_006517.4
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UniProt Primary Accession #
P36021
[Other Products]
UniProt Secondary Accession #
Q7Z797[Other Products]
UniProt Related Accession #
P36021[Other Products]
Molecular Weight
59,511 Da
NCBI Official Full Name
monocarboxylate transporter 8
NCBI Official Synonym Full Names
solute carrier family 16 member 2
NCBI Official Symbol
SLC16A2 [Similar Products]
NCBI Official Synonym Symbols
AHDS; MCT7; MCT8; XPCT; MCT 7; MCT 8; MRX22; DXS128; DXS128E
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NCBI Protein Information
monocarboxylate transporter 8
UniProt Protein Name
Monocarboxylate transporter 8
UniProt Synonym Protein Names
Monocarboxylate transporter 7; MCT 7; Solute carrier family 16 member 2; X-linked PEST-containing transporter
Protein Family
Monocarboxylate transporter
UniProt Gene Name
SLC16A2 [Similar Products]
UniProt Synonym Gene Names
MCT8; XPCT; MCT 8; MCT 7 [Similar Products]
NCBI Summary for SLC16A2
This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]
UniProt Comments for SLC16A2
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
Product References and Citations for anti-SLC16A2 antibody
Endou H., Submitted (MAY-2002). Bentley D.R., Nature 434:325-337(2005). Kuss A.W., Eur. J. Hum. Genet. 16:1029-1037(2008).
Research Articles on SLC16A2
1. Our findings illustrate that different mutations affecting the same residue may have a differential impact on SLC16A2 transporter function, which translates into differences in severity of the clinical phenotype.
Precautions
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Disclaimer
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