Product Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 (Hsd3b6), Recombinant Protein
Full Product Name
Recombinant Rat 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4 (Hsd3b6)
Product Gene Name
Hsd3b6 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-373aa; full length protein
Sequence
PGWSCLVTGA GGFLGQRIVQ LLVQEKDLKE VRVLDKVFRP ETREEFFNLG TSIKVTVLEG DILDTQCLRR ACQGISVVIH TAALIDVTGV NPRQTILDVN LKGTQNLLEA CVQASVPAFI YCSTVDVAGP NSYKKIILNG HEEEHHESTW SNPYPYSKKM AEKAVLAANG SILKNGGTLH TCALRPMYIY GERSPFLSVM ILAALKSKGI LNVTGKFSIA NPVYVGNVAW AHILAARGLR DPKKSQNVQG QFYYISDDTP HQSYDDLNYT LSKEWGLHLD SSWSLPLPLL YWLAFLLEIV SFFLHPVYNY RPSFNRHLVT LSNSKFTFSY KKAQRDLGYK PLVSWEEAKQ KTSEWIGTLV EQHRETLDTK SQ
3D Structure
ModBase 3D Structure for Q62878
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hsd3b6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Hsd3b6 recombinant protein
Transmembrane Protein
Application Notes for Hsd3b6 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Hsd3b6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_058961.4
[Other Products]
NCBI GenBank Nucleotide #
NM_017265.4
[Other Products]
UniProt Primary Accession #
Q62878
[Other Products]
UniProt Secondary Accession #
Q5FVK0[Other Products]
UniProt Related Accession #
Q62878[Other Products]
Molecular Weight
41,957 Da
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
NCBI Official Symbol
Hsd3b6 [Similar Products]
NCBI Official Synonym Symbols
Hsd3b1
[Similar Products]
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV; 3-beta-HSD IV
Protein Family
4-isomerase" title="3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase">3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
UniProt Gene Name
Hsd3b6 [Similar Products]
UniProt Synonym Gene Names
3-beta-HSD IV [Similar Products]
UniProt Entry Name
3BHS4_RAT
NCBI Summary for Hsd3b6
enzyme responsible for the production of progesterone as well as the precursors of androgens, estrogens, glucocorticoids and mineralcorticoids [RGD, Feb 2006]
UniProt Comments for Hsd3b6
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Research Articles on Hsd3b6
1. Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
