Full Product Name
CLN5 Polyclonal Antibody
Product Synonym Names
CLN5; Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5
Product Gene Name
anti-CLN5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human CLN5.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49928 / sc-49931
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CLN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CLN5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLN5 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-CLN5 antibody
Western Blot analysis of 293T cells using CLN5 Polyclonal Antibody at dilution of 1:1000.
NCBI/Uniprot data below describe general gene information for CLN5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006484.1
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NCBI GenBank Nucleotide #
NM_006493.2
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UniProt Secondary Accession #
B3KQK7[Other Products]
UniProt Related Accession #
O75503[Other Products]
Molecular Weight
Calculated MW: 46
Observed MW: 48
NCBI Official Full Name
ceroid-lipofuscinosis neuronal protein 5
NCBI Official Synonym Full Names
ceroid-lipofuscinosis, neuronal 5
NCBI Official Symbol
CLN5 [Similar Products]
NCBI Official Synonym Symbols
NCL
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NCBI Protein Information
ceroid-lipofuscinosis neuronal protein 5
UniProt Protein Name
Ceroid-lipofuscinosis neuronal protein 5
Protein Family
Cln5-like protein
UniProt Gene Name
CLN5 [Similar Products]
UniProt Synonym Gene Names
Protein CLN5 [Similar Products]
UniProt Entry Name
CLN5_HUMAN
NCBI Summary for CLN5
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.[provided by RefSeq, Oct 2008]
UniProt Comments for CLN5
CLN5: Defects in CLN5 are the cause of neuronal ceroid lipofuscinosis type 5 (CLN5); also known as Finnish variant late-infantile neuronal ceroid lipofuscinosis (vLINCL). A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 5 comprise mixed combinations of granular, curvilinear, and fingerprint profiles. Belongs to the CLN5 family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q21.1-q32
Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membrane; lysosomal membrane; lysosome; perinuclear region of cytoplasm
Molecular Function: mannose binding; protein binding
Biological Process: brain development; lysosomal lumen acidification; neurogenesis; neuron maturation; protein catabolic process; signal peptide processing
Disease: Ceroid Lipofuscinosis, Neuronal, 5
Research Articles on CLN5
1. Two forms of CLN5, derived from the C-terminal proteolytic processing, are present in most cells and tissues.
Precautions
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Disclaimer
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