5-HT-2B, Antibody

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (231972947..231989824, complement). Location: 2q36.3-q37.1

Rabbit

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml (lot specific)

Small volumes of anti-5-HT-2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

54,298 Da

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT 2B receptor; serotonin receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b

5-hydroxytryptamine receptor 2B

5-HT-2B; 5-HT2B  [Similar Products]

5HT2B_HUMAN

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: heart morphogenesis; negative regulation of autophagy; cGMP biosynthetic process; phosphoinositide 3-kinase cascade; intestine smooth muscle contraction; behavior; positive regulation of MAP kinase activity; protein kinase C activation; positive regulation of cell proliferation; neural crest cell differentiation; embryonic morphogenesis; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; positive regulation of cytokine production; response to drug; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of cell division; positive regulation of endothelial cell proliferation; phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion

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