Protocadherin 12 (PCDH12), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 5; NC_000005.9 (141324530..141338627, complement). Location: 5q31

Store all reagents at 2-8 degree C

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Small volumes of PCDH12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9311823 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protocadherin 12 (PCDH12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PCDH12. The ELISA analytical biochemical technique of the MBS9311823 kit is based on PCDH12 antibody-PCDH12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PCDH12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PCDH12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

128,995 Da

protocadherin 12

protocadherin-12; VE-cad-2; VE-cadherin 2; vascular cadherin-2; vascular endothelial cadherin 2; vascular endothelial cadherin-2

Protocadherin-12

VE-cad-2  [Similar Products]

PCD12_HUMAN

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth. [provided by RefSeq, Jul 2008]

PCDH12: Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: integral to plasma membrane; plasma membrane; intercellular junction

Molecular Function: calcium ion binding

Biological Process: glycogen metabolic process; calcium-dependent cell-cell adhesion; neuron recognition; homophilic cell adhesion

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